Two sample MR report
genus.Escherichia.Shigella.id.3504 against Lung cancer || id:ebi-a-GCST90018875
Date: 18 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | -0.0527174 | 0.3820555 | 0.8969208 |
| Weighted median | 6 | -0.2280025 | 0.1563382 | 0.1447322 |
| Inverse variance weighted | 6 | -0.3092539 | 0.1167316 | 0.0080665 |
| Simple mode | 6 | -0.0697589 | 0.2411334 | 0.7839668 |
| Weighted mode | 6 | -0.1245727 | 0.2199978 | 0.5956963 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4.730280 | 4 | 0.3161083 |
| Inverse variance weighted | 5.325116 | 5 | 0.3775037 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0225588 | 0.0318075 | 0.5173349 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 2.02e-05 | 0 | TRUE | 0.6385885 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
