

# Two sample MR report

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## eqtl-a-ENSG00000133067 against phenotype

Date: **11 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|     b|    se|  pval|
|:-------------------------|----:|-----:|-----:|-----:|
|MR Egger                  |    6| 0.052| 0.052| 0.374|
|Weighted median           |    6| 0.033| 0.013| 0.011|
|Inverse variance weighted |    6| 0.036| 0.015| 0.017|
|Simple mode               |    6| 0.007| 0.040| 0.869|
|Weighted mode             |    6| 0.032| 0.013| 0.063|

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### Heterogeneity tests


|method                    |    Q| Q_df| Q_pval|
|:-------------------------|----:|----:|------:|
|MR Egger                  | 7.04|    4|  0.134|
|Inverse variance weighted | 7.22|    5|  0.204|

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### Test for directional horizontal pleiotropy


| egger_intercept|    se|  pval|
|---------------:|-----:|-----:|
|          -0.006| 0.018| 0.759|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|           0.001|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/eqtlaENSG00000133067_against_phenotypechunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/eqtlaENSG00000133067_against_phenotypechunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/eqtlaENSG00000133067_against_phenotypechunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/eqtlaENSG00000133067_against_phenotypechunk8-1.png)
