Two sample MR report
Cholesterol levels against phenotype
Date: 21 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -10.541157 | 7.574736 | 0.3966725 |
| Weighted median | 3 | -7.283101 | 3.089781 | 0.0184154 |
| Inverse variance weighted | 3 | -8.523682 | 2.542549 | 0.0008011 |
| Simple mode | 3 | -7.277325 | 3.485326 | 0.1720388 |
| Weighted mode | 3 | -7.251677 | 2.539067 | 0.1038466 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.612478 | 1 | 0.1060260 |
| Inverse variance weighted | 2.846131 | 2 | 0.2409741 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.2939124 | 0.9827842 | 0.8150014 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 3.14e-05 | 2.57e-05 | TRUE | 0.9843405 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
