

# Two sample MR report

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## Lung cancer || id:ieu-b-4954 against Diagnoses - main ICD10: J18 Pneumonia, organism unspecified || id:ukb-d-J18

Date: **21 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|      b|    se|  pval|
|:-------------------------|----:|------:|-----:|-----:|
|MR Egger                  |   17| -0.013| 0.207| 0.952|
|Weighted median           |   17|  0.108| 0.103| 0.293|
|Inverse variance weighted |   17|  0.168| 0.089| 0.060|
|Simple mode               |   17|  0.168| 0.182| 0.371|
|Weighted mode             |   17|  0.154| 0.171| 0.383|

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### Heterogeneity tests


|method                    |    Q| Q_df| Q_pval|
|:-------------------------|----:|----:|------:|
|MR Egger                  | 24.1|   15|  0.063|
|Inverse variance weighted | 25.6|   16|  0.060|

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### Test for directional horizontal pleiotropy


| egger_intercept| se|  pval|
|---------------:|--:|-----:|
|               0|  0| 0.349|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|               0|              0|TRUE                     |         0.92|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Lung_cancer__idieub4954_against_Diagnoses__main_ICD10_J18_Pneumonia_organism_unspecified__idukbdJ18chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Lung_cancer__idieub4954_against_Diagnoses__main_ICD10_J18_Pneumonia_organism_unspecified__idukbdJ18chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Lung_cancer__idieub4954_against_Diagnoses__main_ICD10_J18_Pneumonia_organism_unspecified__idukbdJ18chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Lung_cancer__idieub4954_against_Diagnoses__main_ICD10_J18_Pneumonia_organism_unspecified__idukbdJ18chunk8-1.png)
