Two sample MR report
Lung cancer || id:ieu-b-4954 against Diagnoses - main ICD10: J18 Pneumonia, organism unspecified || id:ukb-d-J18
Date: 21 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 17 | -0.013 | 0.207 | 0.952 |
| Weighted median | 17 | 0.108 | 0.103 | 0.293 |
| Inverse variance weighted | 17 | 0.168 | 0.089 | 0.060 |
| Simple mode | 17 | 0.168 | 0.182 | 0.371 |
| Weighted mode | 17 | 0.154 | 0.171 | 0.383 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 24.1 | 15 | 0.063 |
| Inverse variance weighted | 25.6 | 16 | 0.060 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0 | 0 | 0.349 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.92 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
