

# Two sample MR report

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## k__Bacteria|p__Firmicutes|c__Bacilli|o__Erysipelotrichales|f__Erysipelotrichaceae|g__Solobacterium|s__unclassified_mgs_2806 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.0167559| 0.0317047| 0.6251187|
|Weighted median           |    6|  0.0015846| 0.0011547| 0.1699679|
|Inverse variance weighted |    6|  0.0020009| 0.0009057| 0.0271563|
|Simple mode               |    6|  0.0015660| 0.0016686| 0.3910556|
|Weighted mode             |    6|  0.0015518| 0.0015725| 0.3690371|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.266961|    4| 0.8669557|
|Inverse variance weighted | 1.617245|    5| 0.8991561|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0019897| 0.0033619| 0.5857839|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0009388|              0|TRUE                     |    0.1860171|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescBacillioErysipelotrichalesfErysipelotrichaceaegSolobacteriumsunclassifiedmgs2806_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescBacillioErysipelotrichalesfErysipelotrichaceaegSolobacteriumsunclassifiedmgs2806_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescBacillioErysipelotrichalesfErysipelotrichaceaegSolobacteriumsunclassifiedmgs2806_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescBacillioErysipelotrichalesfErysipelotrichaceaegSolobacteriumsunclassifiedmgs2806_against_ebiaGCST90038645chunk8-1.png)
