

# Two sample MR report

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## k__Bacteria|p__Firmicutes|c__Bacilli|o__RF39|f__CAG-611|g__RUG343 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5|  0.0299577| 0.0550450| 0.6241209|
|Weighted median           |    5| -0.0022157| 0.0015029| 0.1404173|
|Inverse variance weighted |    5| -0.0025608| 0.0011302| 0.0234610|
|Simple mode               |    5| -0.0022339| 0.0019348| 0.3125436|
|Weighted mode             |    5| -0.0020860| 0.0014824| 0.2321306|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.491434|    3| 0.3218747|
|Inverse variance weighted | 3.897803|    4| 0.4200133|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0035223| 0.0059609| 0.5961475|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0007015|              0|TRUE                     |    0.2561262|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescBacillioRF39fCAG611gRUG343_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescBacillioRF39fCAG611gRUG343_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescBacillioRF39fCAG611gRUG343_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescBacillioRF39fCAG611gRUG343_against_ebiaGCST90038645chunk8-1.png)
