

# Two sample MR report

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## k__Bacteria|p__Firmicutes|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella|s__Veillonella_rogosae_mgs_2039 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    5| 0.0089336| 0.0466800| 0.8604482|
|Weighted median           |    5| 0.0021184| 0.0011799| 0.0725807|
|Inverse variance weighted |    5| 0.0019527| 0.0009440| 0.0385992|
|Simple mode               |    5| 0.0026333| 0.0015671| 0.1681737|
|Weighted mode             |    5| 0.0021779| 0.0014945| 0.2187685|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.088338|    3| 0.5542757|
|Inverse variance weighted | 2.110712|    4| 0.7154047|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0007396| 0.0049444| 0.8905864|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0008628|              0|TRUE                     |    0.2049535|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescNegativicutesoVeillonellalesfVeillonellaceaegVeillonellasVeillonellarogosaemgs2039_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescNegativicutesoVeillonellalesfVeillonellaceaegVeillonellasVeillonellarogosaemgs2039_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescNegativicutesoVeillonellalesfVeillonellaceaegVeillonellasVeillonellarogosaemgs2039_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescNegativicutesoVeillonellalesfVeillonellaceaegVeillonellasVeillonellarogosaemgs2039_against_ebiaGCST90038645chunk8-1.png)
