

# Two sample MR report

---

## k__Bacteria|p__Actinobacteriota|c__Actinobacteria|o__Actinomycetales|f__Actinomycetaceae|g__Pauljensenia|s__unclassified_mgs_2911 against ebi-a-GCST90038645

Date: **14 February, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7|  0.0021432| 0.0276006| 0.9411189|
|Weighted median           |    7| -0.0031946| 0.0013027| 0.0141965|
|Inverse variance weighted |    7| -0.0021865| 0.0009813| 0.0258754|
|Simple mode               |    7| -0.0033585| 0.0019529| 0.1362744|
|Weighted mode             |    7| -0.0034515| 0.0019146| 0.1214938|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.806051|    5| 0.7298567|
|Inverse variance weighted | 2.830690|    6| 0.8297773|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0004664| 0.0029713| 0.8814118|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0009701|              0|TRUE                     |    0.1793302|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapActinobacteriotacActinobacteriaoActinomycetalesfActinomycetaceaegPauljenseniasunclassifiedmgs2911_against_ebiaGCST90038645chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapActinobacteriotacActinobacteriaoActinomycetalesfActinomycetaceaegPauljenseniasunclassifiedmgs2911_against_ebiaGCST90038645chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/kBacteriapActinobacteriotacActinobacteriaoActinomycetalesfActinomycetaceaegPauljenseniasunclassifiedmgs2911_against_ebiaGCST90038645chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapActinobacteriotacActinobacteriaoActinomycetalesfActinomycetaceaegPauljenseniasunclassifiedmgs2911_against_ebiaGCST90038645chunk8-1.png)
