

# Two sample MR report

---

## k__Bacteria|p__Firmicutes|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__unclassified_mgs_1680 against ebi-a-GCST90038645

Date: **14 February, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7| -0.0685748| 0.0820184| 0.4412165|
|Weighted median           |    7|  0.0013943| 0.0010675| 0.1915213|
|Inverse variance weighted |    7|  0.0018527| 0.0007941| 0.0196402|
|Simple mode               |    7|  0.0008255| 0.0015463| 0.6126184|
|Weighted mode             |    7|  0.0010420| 0.0013351| 0.4647731|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.327440|    5| 0.5032977|
|Inverse variance weighted | 5.064839|    6| 0.5355243|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0074394| 0.0086633| 0.4297302|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0010469|              0|TRUE                     |    0.1635589|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussunclassifiedmgs1680_against_ebiaGCST90038645chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussunclassifiedmgs1680_against_ebiaGCST90038645chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussunclassifiedmgs1680_against_ebiaGCST90038645chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussunclassifiedmgs1680_against_ebiaGCST90038645chunk8-1.png)
