

# Two sample MR report

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## k__Bacteria|p__Firmicutes|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__unclassified_mgs_2388 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.0041555| 0.0782435| 0.9662211|
|Weighted median           |    3| -0.0034285| 0.0019865| 0.0843662|
|Inverse variance weighted |    3| -0.0034185| 0.0017028| 0.0446953|
|Simple mode               |    3| -0.0034377| 0.0023892| 0.2868060|
|Weighted mode             |    3| -0.0034270| 0.0020861| 0.2421367|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0048658|    1| 0.9443887|
|Inverse variance weighted | 0.0049545|    2| 0.9975258|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|         8.2e-05| 0.0087059| 0.994002|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0005763|              0|TRUE                     |    0.3007164|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussunclassifiedmgs2388_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussunclassifiedmgs2388_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussunclassifiedmgs2388_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussunclassifiedmgs2388_against_ebiaGCST90038645chunk8-1.png)
