

# Two sample MR report

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## k__Bacteria|p__Firmicutes|c__Bacilli|o__Staphylococcales|f__Gemellaceae|g__Gemella|s__unclassified_mgs_2041 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 0.0103920| 0.0130787| 0.4713422|
|Weighted median           |    6| 0.0020808| 0.0011115| 0.0611904|
|Inverse variance weighted |    6| 0.0019568| 0.0008790| 0.0260022|
|Simple mode               |    6| 0.0025848| 0.0016601| 0.1801972|
|Weighted mode             |    6| 0.0022509| 0.0015463| 0.2052410|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.073036|    4| 0.7223275|
|Inverse variance weighted | 2.490896|    5| 0.7778656|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.0009444| 0.001461| 0.5532265|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0010006|              0|TRUE                     |    0.1723334|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescBacillioStaphylococcalesfGemellaceaegGemellasunclassifiedmgs2041_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescBacillioStaphylococcalesfGemellaceaegGemellasunclassifiedmgs2041_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescBacillioStaphylococcalesfGemellaceaegGemellasunclassifiedmgs2041_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescBacillioStaphylococcalesfGemellaceaegGemellasunclassifiedmgs2041_against_ebiaGCST90038645chunk8-1.png)
