

# Two sample MR report

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## k__Bacteria|p__Firmicutes|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum|s__unclassified_mgs_48 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    9| -0.0014281| 0.0164910| 0.9334144|
|Weighted median           |    9|  0.0014215| 0.0009603| 0.1387901|
|Inverse variance weighted |    9|  0.0014091| 0.0007076| 0.0464355|
|Simple mode               |    9|  0.0031539| 0.0016883| 0.0987069|
|Weighted mode             |    9| -0.0003845| 0.0014693| 0.8001923|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 7.989700|    7| 0.3335030|
|Inverse variance weighted | 8.023558|    8| 0.4311723|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0003049| 0.0017701| 0.8681306|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0014035|              0|TRUE                     |    0.1062951|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescClostridiaoLachnospiralesfLachnospiraceaegStomatobaculumsunclassifiedmgs48_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescClostridiaoLachnospiralesfLachnospiraceaegStomatobaculumsunclassifiedmgs48_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescClostridiaoLachnospiralesfLachnospiraceaegStomatobaculumsunclassifiedmgs48_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescClostridiaoLachnospiralesfLachnospiraceaegStomatobaculumsunclassifiedmgs48_against_ebiaGCST90038645chunk8-1.png)
