

# Two sample MR report

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## k__Bacteria|p__Campylobacterota|c__Campylobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter_A|s__unclassified_mgs_1157 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    7| 0.0018644| 0.0538963| 0.9737432|
|Weighted median           |    7| 0.0026336| 0.0013405| 0.0494664|
|Inverse variance weighted |    7| 0.0025182| 0.0010290| 0.0143982|
|Simple mode               |    7| 0.0026797| 0.0016951| 0.1649969|
|Weighted mode             |    7| 0.0023742| 0.0013540| 0.1300694|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.364264|    5| 0.7967838|
|Inverse variance weighted | 2.364411|    6| 0.8833229|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|        7.02e-05| 0.0057894| 0.9907893|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0009399|              0|TRUE                     |    0.1861531|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapCampylobacterotacCampylobacteriaoCampylobacteralesfCampylobacteraceaegCampylobacterAsunclassifiedmgs1157_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapCampylobacterotacCampylobacteriaoCampylobacteralesfCampylobacteraceaegCampylobacterAsunclassifiedmgs1157_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapCampylobacterotacCampylobacteriaoCampylobacteralesfCampylobacteraceaegCampylobacterAsunclassifiedmgs1157_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapCampylobacterotacCampylobacteriaoCampylobacteralesfCampylobacteraceaegCampylobacterAsunclassifiedmgs1157_against_ebiaGCST90038645chunk8-1.png)
