

# Two sample MR report

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## k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Bacteroidaceae|g__F0040|s__F0040_sp900095835_mgs_1710 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.0005571| 0.0612409| 0.9942091|
|Weighted median           |    3| 0.0034897| 0.0020199| 0.0840507|
|Inverse variance weighted |    3| 0.0037301| 0.0016444| 0.0233071|
|Simple mode               |    3| 0.0030261| 0.0023616| 0.3285575|
|Weighted mode             |    3| 0.0032981| 0.0020766| 0.2531692|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.3905571|    1| 0.5320067|
|Inverse variance weighted | 0.3932435|    2| 0.8215013|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0003655| 0.0070523| 0.9670332|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004971|              0|TRUE                     |    0.3360424|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfBacteroidaceaegF0040sF0040sp900095835mgs1710_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfBacteroidaceaegF0040sF0040sp900095835mgs1710_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfBacteroidaceaegF0040sF0040sp900095835mgs1710_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfBacteroidaceaegF0040sF0040sp900095835mgs1710_against_ebiaGCST90038645chunk8-1.png)
