

# Two sample MR report

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## k__Bacteria|p__Campylobacterota|c__Campylobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter_A|s__unclassified_mgs_2223 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.0911799| 0.0483948| 0.1560636|
|Weighted median           |    5|  0.0013147| 0.0011786| 0.2646653|
|Inverse variance weighted |    5|  0.0021263| 0.0009619| 0.0270624|
|Simple mode               |    5|  0.0039279| 0.0017363| 0.0864638|
|Weighted mode             |    5|  0.0004946| 0.0015707| 0.7685814|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.005056|    3| 0.8000286|
|Inverse variance weighted | 4.723567|    4| 0.3168547|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|        0.010023| 0.0051977| 0.1494088|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0008274|              0|TRUE                     |    0.2153964|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapCampylobacterotacCampylobacteriaoCampylobacteralesfCampylobacteraceaegCampylobacterAsunclassifiedmgs2223_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapCampylobacterotacCampylobacteriaoCampylobacteralesfCampylobacteraceaegCampylobacterAsunclassifiedmgs2223_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapCampylobacterotacCampylobacteriaoCampylobacteralesfCampylobacteraceaegCampylobacterAsunclassifiedmgs2223_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapCampylobacterotacCampylobacteriaoCampylobacteralesfCampylobacteraceaegCampylobacterAsunclassifiedmgs2223_against_ebiaGCST90038645chunk8-1.png)
