

# Two sample MR report

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## k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia|s__unclassified_mgs_227 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.0561524| 0.0613530| 0.4118512|
|Weighted median           |    6|  0.0024064| 0.0012328| 0.0509340|
|Inverse variance weighted |    6|  0.0023161| 0.0009526| 0.0150457|
|Simple mode               |    6|  0.0024816| 0.0015505| 0.1703866|
|Weighted mode             |    6|  0.0024816| 0.0014169| 0.1402652|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.020870|    4| 0.9066152|
|Inverse variance weighted | 1.929269|    5| 0.8588430|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0064112| 0.0067267| 0.3945114|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0008905|              0|TRUE                     |    0.1984381|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFusobacteriotacFusobacteriiaoFusobacterialesfLeptotrichiaceaegLeptotrichiasunclassifiedmgs227_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFusobacteriotacFusobacteriiaoFusobacterialesfLeptotrichiaceaegLeptotrichiasunclassifiedmgs227_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFusobacteriotacFusobacteriiaoFusobacterialesfLeptotrichiaceaegLeptotrichiasunclassifiedmgs227_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFusobacteriotacFusobacteriiaoFusobacterialesfLeptotrichiaceaegLeptotrichiasunclassifiedmgs227_against_ebiaGCST90038645chunk8-1.png)
