

# Two sample MR report

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## k__Bacteria|p__Proteobacteria|c__Gammaproteobacteria|o__Enterobacterales|f__Pasteurellaceae|g__Aggregatibacter|s__Aggregatibacter_sp000466335_mgs_2597 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    5| 0.0488727| 0.0490212| 0.3922566|
|Weighted median           |    5| 0.0029576| 0.0013919| 0.0335975|
|Inverse variance weighted |    5| 0.0022164| 0.0010954| 0.0430448|
|Simple mode               |    5| 0.0032302| 0.0021939| 0.2148987|
|Weighted mode             |    5| 0.0035456| 0.0019224| 0.1388941|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.405521|    3| 0.3332240|
|Inverse variance weighted | 4.434337|    4| 0.3504045|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0050924| 0.0053491| 0.4113293|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000724|              0|TRUE                     |    0.2467699|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegAggregatibactersAggregatibactersp000466335mgs2597_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegAggregatibactersAggregatibactersp000466335mgs2597_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegAggregatibactersAggregatibactersp000466335mgs2597_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegAggregatibactersAggregatibactersp000466335mgs2597_against_ebiaGCST90038645chunk8-1.png)
