

# Two sample MR report

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## k__Bacteria|p__Proteobacteria|c__Gammaproteobacteria|o__Enterobacterales|f__Pasteurellaceae|g__Haemophilus|s__unclassified_mgs_2527 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5|  0.0603242| 0.1128129| 0.6299312|
|Weighted median           |    5| -0.0027214| 0.0013331| 0.0412019|
|Inverse variance weighted |    5| -0.0029933| 0.0010476| 0.0042720|
|Simple mode               |    5| -0.0026100| 0.0018395| 0.2289316|
|Weighted mode             |    5| -0.0024698| 0.0019291| 0.2696437|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.682279|    3| 0.6408807|
|Inverse variance weighted | 1.997320|    4| 0.7362518|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0067286| 0.0119879| 0.6138002|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0006481|              0|TRUE                     |    0.2735009|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegHaemophilussunclassifiedmgs2527_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegHaemophilussunclassifiedmgs2527_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegHaemophilussunclassifiedmgs2527_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegHaemophilussunclassifiedmgs2527_against_ebiaGCST90038645chunk8-1.png)
