

# Two sample MR report

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## k__Bacteria|p__Spirochaetota|c__Spirochaetia|o__Treponematales|f__Treponemataceae|g__Treponema_A|s__unclassified_mgs_35 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7|  0.0466795| 0.0297752| 0.1777295|
|Weighted median           |    7| -0.0019348| 0.0010551| 0.0667004|
|Inverse variance weighted |    7| -0.0016423| 0.0007724| 0.0334832|
|Simple mode               |    7| -0.0016765| 0.0015363| 0.3170219|
|Weighted mode             |    7| -0.0016498| 0.0014224| 0.2901480|

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### Heterogeneity tests


|method                    |       Q| Q_df|    Q_pval|
|:-------------------------|-------:|----:|---------:|
|MR Egger                  | 2.37947|    5| 0.7945275|
|Inverse variance weighted | 5.01501|    6| 0.5418894|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|     pval|
|---------------:|--------:|--------:|
|      -0.0051057| 0.003145| 0.165424|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0010838|              0|TRUE                     |    0.1555831|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapSpirochaetotacSpirochaetiaoTreponematalesfTreponemataceaegTreponemaAsunclassifiedmgs35_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapSpirochaetotacSpirochaetiaoTreponematalesfTreponemataceaegTreponemaAsunclassifiedmgs35_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapSpirochaetotacSpirochaetiaoTreponematalesfTreponemataceaegTreponemaAsunclassifiedmgs35_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapSpirochaetotacSpirochaetiaoTreponematalesfTreponemataceaegTreponemaAsunclassifiedmgs35_against_ebiaGCST90038645chunk8-1.png)
