

# Two sample MR report

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## k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Fusobacteriaceae|g__Fusobacterium|s__unclassified_mgs_2355 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4|  0.0229751| 0.0280855| 0.4992907|
|Weighted median           |    4| -0.0027120| 0.0012922| 0.0358346|
|Inverse variance weighted |    4| -0.0021386| 0.0010110| 0.0344065|
|Simple mode               |    4| -0.0031804| 0.0018775| 0.1888594|
|Weighted mode             |    4| -0.0032573| 0.0019391| 0.1915792|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.316803|    2| 0.5176782|
|Inverse variance weighted | 2.117416|    3| 0.5483975|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0027576| 0.0030819| 0.4653313|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0007126|              0|TRUE                     |    0.2511338|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFusobacteriotacFusobacteriiaoFusobacterialesfFusobacteriaceaegFusobacteriumsunclassifiedmgs2355_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFusobacteriotacFusobacteriiaoFusobacterialesfFusobacteriaceaegFusobacteriumsunclassifiedmgs2355_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFusobacteriotacFusobacteriiaoFusobacterialesfFusobacteriaceaegFusobacteriumsunclassifiedmgs2355_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFusobacteriotacFusobacteriiaoFusobacterialesfFusobacteriaceaegFusobacteriumsunclassifiedmgs2355_against_ebiaGCST90038645chunk8-1.png)
