

# Two sample MR report

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## k__Bacteria|p__Patescibacteria|c__Gracilibacteria|o__Absconditabacterales|f__X112|g__HOT-345|s__unclassified_mgs_3129 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   10| -0.0133490| 0.0250114| 0.6080441|
|Weighted median           |   10|  0.0015485| 0.0009675| 0.1094731|
|Inverse variance weighted |   10|  0.0017130| 0.0007061| 0.0152720|
|Simple mode               |   10|  0.0015183| 0.0013895| 0.3028916|
|Weighted mode             |   10|  0.0015580| 0.0013284| 0.2709712|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 5.670044|    8| 0.6841364|
|Inverse variance weighted | 6.032983|    9| 0.7366127|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0016649| 0.0027636| 0.5635608|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0016504|              0|TRUE                     |      0.07941|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapPatescibacteriacGracilibacteriaoAbsconditabacteralesfX112gHOT345sunclassifiedmgs3129_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapPatescibacteriacGracilibacteriaoAbsconditabacteralesfX112gHOT345sunclassifiedmgs3129_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapPatescibacteriacGracilibacteriaoAbsconditabacteralesfX112gHOT345sunclassifiedmgs3129_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapPatescibacteriacGracilibacteriaoAbsconditabacteralesfX112gHOT345sunclassifiedmgs3129_against_ebiaGCST90038645chunk8-1.png)
