

# Two sample MR report

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## k__Bacteria|p__Actinobacteriota|c__Actinobacteria|o__Actinomycetales|f__Actinomycetaceae|g__Pauljensenia|s__unclassified_mgs_1959 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.2997132| 0.2457297| 0.4371971|
|Weighted median           |    3|  0.0035960| 0.0023200| 0.1211505|
|Inverse variance weighted |    3|  0.0041142| 0.0020037| 0.0400456|
|Simple mode               |    3|  0.0038111| 0.0037836| 0.4198618|
|Weighted mode             |    3|  0.0035643| 0.0022157| 0.2489602|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0072396|    1| 0.9321931|
|Inverse variance weighted | 1.5360981|    2| 0.4639173|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|       0.0336633| 0.0272253| 0.432937|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0005908|              0|TRUE                     |    0.2946144|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapActinobacteriotacActinobacteriaoActinomycetalesfActinomycetaceaegPauljenseniasunclassifiedmgs1959_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapActinobacteriotacActinobacteriaoActinomycetalesfActinomycetaceaegPauljenseniasunclassifiedmgs1959_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapActinobacteriotacActinobacteriaoActinomycetalesfActinomycetaceaegPauljenseniasunclassifiedmgs1959_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapActinobacteriotacActinobacteriaoActinomycetalesfActinomycetaceaegPauljenseniasunclassifiedmgs1959_against_ebiaGCST90038645chunk8-1.png)
