

# Two sample MR report

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## k__Bacteria|p__Patescibacteria|c__Saccharimonadia|o__Saccharimonadales|f__Saccharimonadaceae|g__unclassified_mgs_2228 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.0114015| 0.0266151| 0.7100957|
|Weighted median           |    4|  0.0019303| 0.0012123| 0.1113325|
|Inverse variance weighted |    4|  0.0023553| 0.0009719| 0.0153793|
|Simple mode               |    4|  0.0030700| 0.0015178| 0.1363154|
|Weighted mode             |    4|  0.0019250| 0.0015164| 0.2938249|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1217757|    2| 0.9409288|
|Inverse variance weighted | 0.3892938|    3| 0.9424452|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       0.0015191| 0.002937| 0.6565202|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000578|              0|TRUE                     |    0.3010502|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapPatescibacteriacSaccharimonadiaoSaccharimonadalesfSaccharimonadaceaegunclassifiedmgs2228_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapPatescibacteriacSaccharimonadiaoSaccharimonadalesfSaccharimonadaceaegunclassifiedmgs2228_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapPatescibacteriacSaccharimonadiaoSaccharimonadalesfSaccharimonadaceaegunclassifiedmgs2228_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapPatescibacteriacSaccharimonadiaoSaccharimonadalesfSaccharimonadaceaegunclassifiedmgs2228_against_ebiaGCST90038645chunk8-1.png)
