

# Two sample MR report

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## k__Bacteria|p__Patescibacteria|c__Saccharimonadia|o__Saccharimonadales|f__Saccharimonadaceae|g__unclassified_mgs_549|s__unclassified_mgs_549 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6|  0.0102620| 0.1490685| 0.9484204|
|Weighted median           |    6| -0.0027429| 0.0013071| 0.0358672|
|Inverse variance weighted |    6| -0.0022990| 0.0010868| 0.0343990|
|Simple mode               |    6| -0.0037911| 0.0022007| 0.1455518|
|Weighted mode             |    6| -0.0035751| 0.0021497| 0.1571882|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 6.107370|    4| 0.1912720|
|Inverse variance weighted | 6.118212|    5| 0.2948858|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0013354| 0.0158472| 0.9368938|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0007858|              0|TRUE                     |    0.2315241|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapPatescibacteriacSaccharimonadiaoSaccharimonadalesfSaccharimonadaceaegunclassifiedmgs549sunclassifiedmgs549_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapPatescibacteriacSaccharimonadiaoSaccharimonadalesfSaccharimonadaceaegunclassifiedmgs549sunclassifiedmgs549_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapPatescibacteriacSaccharimonadiaoSaccharimonadalesfSaccharimonadaceaegunclassifiedmgs549sunclassifiedmgs549_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapPatescibacteriacSaccharimonadiaoSaccharimonadalesfSaccharimonadaceaegunclassifiedmgs549sunclassifiedmgs549_against_ebiaGCST90038645chunk8-1.png)
