

# Two sample MR report

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## k__Bacteria|p__Firmicutes|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__unclassified_mgs_121|s__unclassified_mgs_121 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.1049310| 0.0468105| 0.0884637|
|Weighted median           |    6| -0.0015017| 0.0013488| 0.2655616|
|Inverse variance weighted |    6| -0.0022995| 0.0009988| 0.0213250|
|Simple mode               |    6| -0.0000367| 0.0021729| 0.9871639|
|Weighted mode             |    6| -0.0038757| 0.0017576| 0.0785856|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.2145646|    4| 0.9946407|
|Inverse variance weighted | 5.0237530|    5| 0.4129882|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       0.0110351| 0.005032| 0.0933803|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0008749|              0|TRUE                     |    0.2022438|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescClostridiaoLachnospiralesfLachnospiraceaegunclassifiedmgs121sunclassifiedmgs121_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescClostridiaoLachnospiralesfLachnospiraceaegunclassifiedmgs121sunclassifiedmgs121_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescClostridiaoLachnospiralesfLachnospiraceaegunclassifiedmgs121sunclassifiedmgs121_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescClostridiaoLachnospiralesfLachnospiraceaegunclassifiedmgs121sunclassifiedmgs121_against_ebiaGCST90038645chunk8-1.png)
