

# Two sample MR report

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## k__Bacteria|p__Firmicutes|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus_sanguinis_mgs_3170 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    7| 0.0069613| 0.0504713| 0.8956818|
|Weighted median           |    7| 0.0002855| 0.0013224| 0.8290637|
|Inverse variance weighted |    7| 0.0020399| 0.0009879| 0.0389324|
|Simple mode               |    7| 0.0001537| 0.0019174| 0.9387184|
|Weighted mode             |    7| 0.0001537| 0.0017197| 0.9316966|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 6.987967|    5| 0.2215367|
|Inverse variance weighted | 7.001261|    6| 0.3207306|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0005237| 0.0053698| 0.9260942|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0010939|              0|TRUE                     |    0.1535222|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussStreptococcussanguinismgs3170_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussStreptococcussanguinismgs3170_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussStreptococcussanguinismgs3170_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussStreptococcussanguinismgs3170_against_ebiaGCST90038645chunk8-1.png)
