

# Two sample MR report

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## k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga|s__unclassified_mgs_2361 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   10| -0.0316711| 0.0254803| 0.2490744|
|Weighted median           |   10|  0.0014633| 0.0009974| 0.1423359|
|Inverse variance weighted |   10|  0.0014357| 0.0007151| 0.0446899|
|Simple mode               |   10|  0.0026917| 0.0016774| 0.1430314|
|Weighted mode             |   10|  0.0020776| 0.0015150| 0.2034794|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 5.241977|    8| 0.7314279|
|Inverse variance weighted | 6.931509|    9| 0.6442503|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0035391| 0.0027228| 0.2298623|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0013448|              0|TRUE                     |    0.1131516|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapBacteroidotacBacteroidiaoFlavobacterialesfFlavobacteriaceaegCapnocytophagasunclassifiedmgs2361_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapBacteroidotacBacteroidiaoFlavobacterialesfFlavobacteriaceaegCapnocytophagasunclassifiedmgs2361_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapBacteroidotacBacteroidiaoFlavobacterialesfFlavobacteriaceaegCapnocytophagasunclassifiedmgs2361_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapBacteroidotacBacteroidiaoFlavobacterialesfFlavobacteriaceaegCapnocytophagasunclassifiedmgs2361_against_ebiaGCST90038645chunk8-1.png)
