

# Two sample MR report

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## k__Bacteria|p__Firmicutes|c__Bacilli|o__Erysipelotrichales|f__Erysipelotrichaceae|g__Solobacterium|s__unclassified_mgs_2949 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    8| -0.0180934| 0.0189289| 0.3760533|
|Weighted median           |    8|  0.0009758| 0.0010851| 0.3685193|
|Inverse variance weighted |    8|  0.0017242| 0.0008078| 0.0328123|
|Simple mode               |    8|  0.0009031| 0.0014425| 0.5511524|
|Weighted mode             |    8|  0.0009308| 0.0013168| 0.5024893|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.687923|    6| 0.5844157|
|Inverse variance weighted | 5.786026|    7| 0.5649445|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0021761| 0.0020766| 0.3350485|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0011937|              0|TRUE                     |    0.1372068|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescBacillioErysipelotrichalesfErysipelotrichaceaegSolobacteriumsunclassifiedmgs2949_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescBacillioErysipelotrichalesfErysipelotrichaceaegSolobacteriumsunclassifiedmgs2949_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescBacillioErysipelotrichalesfErysipelotrichaceaegSolobacteriumsunclassifiedmgs2949_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescBacillioErysipelotrichalesfErysipelotrichaceaegSolobacteriumsunclassifiedmgs2949_against_ebiaGCST90038645chunk8-1.png)
