

# Two sample MR report

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## k__Bacteria|p__Proteobacteria|c__Gammaproteobacteria|o__Enterobacterales|f__Pasteurellaceae|g__Aggregatibacter|s__Aggregatibacter_sp000466335_mgs_2558 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.0526793| 0.0486087| 0.3578042|
|Weighted median           |    5| -0.0021736| 0.0013797| 0.1151649|
|Inverse variance weighted |    5| -0.0020942| 0.0010292| 0.0418727|
|Simple mode               |    5| -0.0026755| 0.0017683| 0.2048260|
|Weighted mode             |    5| -0.0022948| 0.0018178| 0.2753938|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.817595|    3| 0.6111136|
|Inverse variance weighted | 2.901049|    4| 0.5745188|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|        0.005335| 0.0051254| 0.3744372|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000656|              0|TRUE                     |     0.270204|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegAggregatibactersAggregatibactersp000466335mgs2558_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegAggregatibactersAggregatibactersp000466335mgs2558_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegAggregatibactersAggregatibactersp000466335mgs2558_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegAggregatibactersAggregatibactersp000466335mgs2558_against_ebiaGCST90038645chunk8-1.png)
