

# Two sample MR report

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## k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Bacteroidaceae|g__Prevotella|s__unclassified_mgs_3569 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7| -0.0712899| 0.0510810| 0.2216388|
|Weighted median           |    7|  0.0014896| 0.0010675| 0.1628870|
|Inverse variance weighted |    7|  0.0017670| 0.0008402| 0.0354705|
|Simple mode               |    7|  0.0015809| 0.0014333| 0.3123149|
|Weighted mode             |    7|  0.0014747| 0.0012673| 0.2887290|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.7180283|    5| 0.9819646|
|Inverse variance weighted | 2.7640981|    6| 0.8378190|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|  pval|
|---------------:|---------:|-----:|
|       0.0077275| 0.0054023| 0.212|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0009358|              0|TRUE                     |    0.1900717|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfBacteroidaceaegPrevotellasunclassifiedmgs3569_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfBacteroidaceaegPrevotellasunclassifiedmgs3569_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfBacteroidaceaegPrevotellasunclassifiedmgs3569_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfBacteroidaceaegPrevotellasunclassifiedmgs3569_against_ebiaGCST90038645chunk8-1.png)
