

# Two sample MR report

---

## k__Bacteria|p__Firmicutes|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__unclassified_mgs_1034 against ebi-a-GCST90038645

Date: **14 February, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.0273960| 0.0263264| 0.3745407|
|Weighted median           |    5|  0.0024958| 0.0012550| 0.0467273|
|Inverse variance weighted |    5|  0.0024637| 0.0009363| 0.0085091|
|Simple mode               |    5|  0.0032340| 0.0016079| 0.1146197|
|Weighted mode             |    5|  0.0029564| 0.0014031| 0.1028408|

---

### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1755093|    3| 0.9814426|
|Inverse variance weighted | 1.4635777|    4| 0.8330730|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0032262| 0.0028426| 0.3388805|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0011529|              0|TRUE                     |    0.1430129|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussunclassifiedmgs1034_against_ebiaGCST90038645chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussunclassifiedmgs1034_against_ebiaGCST90038645chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussunclassifiedmgs1034_against_ebiaGCST90038645chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussunclassifiedmgs1034_against_ebiaGCST90038645chunk8-1.png)
