

# Two sample MR report

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## k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella|s__Tannerella_sp002890585_mgs_2607 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5|  0.0018100| 0.0177003| 0.9250047|
|Weighted median           |    5| -0.0021481| 0.0012864| 0.0949517|
|Inverse variance weighted |    5| -0.0023730| 0.0010699| 0.0265642|
|Simple mode               |    5| -0.0022226| 0.0017950| 0.2833481|
|Weighted mode             |    5| -0.0021828| 0.0015671| 0.2360762|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.314982|    3| 0.7255785|
|Inverse variance weighted | 1.371035|    4| 0.8492134|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|     pval|
|---------------:|--------:|--------:|
|      -0.0004766| 0.002013| 0.828093|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0011263|              0|TRUE                     |    0.1485126|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfTannerellaceaegTannerellasTannerellasp002890585mgs2607_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfTannerellaceaegTannerellasTannerellasp002890585mgs2607_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfTannerellaceaegTannerellasTannerellasp002890585mgs2607_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfTannerellaceaegTannerellasTannerellasp002890585mgs2607_against_ebiaGCST90038645chunk8-1.png)
