

# Two sample MR report

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## k__Bacteria|p__Firmicutes|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__unclassified_mgs_2358 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.0568886| 0.0487139| 0.3077438|
|Weighted median           |    6|  0.0018351| 0.0013766| 0.1824999|
|Inverse variance weighted |    6|  0.0028033| 0.0014174| 0.0479513|
|Simple mode               |    6| -0.0001048| 0.0030593| 0.9740024|
|Weighted mode             |    6| -0.0002638| 0.0029163| 0.9314275|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  |  8.815964|    4| 0.0658678|
|Inverse variance weighted | 12.127812|    5| 0.0330778|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0065715| 0.0053608| 0.2874972|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0010392|              0|TRUE                     |    0.1651952|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussunclassifiedmgs2358_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussunclassifiedmgs2358_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussunclassifiedmgs2358_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescBacillioLactobacillalesfStreptococcaceaegStreptococcussunclassifiedmgs2358_against_ebiaGCST90038645chunk8-1.png)
