

# Two sample MR report

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## k__Bacteria|p__Firmicutes|c__Bacilli|o__Erysipelotrichales|f__Erysipelotrichaceae|g__Solobacterium|s__unclassified_mgs_3502 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.1605208| 0.1066144| 0.2066236|
|Weighted median           |    6|  0.0025385| 0.0012947| 0.0499127|
|Inverse variance weighted |    6|  0.0022618| 0.0010588| 0.0326623|
|Simple mode               |    6|  0.0033345| 0.0018205| 0.1265114|
|Weighted mode             |    6|  0.0034445| 0.0014997| 0.0700551|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.882741|    4| 0.4221076|
|Inverse variance weighted | 6.214148|    5| 0.2859356|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0175081| 0.0114665| 0.2014961|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0009888|              0|TRUE                     |     0.177037|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescBacillioErysipelotrichalesfErysipelotrichaceaegSolobacteriumsunclassifiedmgs3502_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescBacillioErysipelotrichalesfErysipelotrichaceaegSolobacteriumsunclassifiedmgs3502_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescBacillioErysipelotrichalesfErysipelotrichaceaegSolobacteriumsunclassifiedmgs3502_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescBacillioErysipelotrichalesfErysipelotrichaceaegSolobacteriumsunclassifiedmgs3502_against_ebiaGCST90038645chunk8-1.png)
