

# Two sample MR report

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## k__Bacteria|p__Firmicutes|c__Clostridia|o__Tissierellales|f__Helcococcaceae|g__W5053|s__W5053_sp000467935_mgs_712 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 0.0004772| 0.0213090| 0.9832049|
|Weighted median           |    6| 0.0020934| 0.0010840| 0.0534662|
|Inverse variance weighted |    6| 0.0019336| 0.0008147| 0.0176187|
|Simple mode               |    6| 0.0026061| 0.0015642| 0.1565638|
|Weighted mode             |    6| 0.0022272| 0.0015250| 0.2039927|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.055257|    4| 0.3985792|
|Inverse variance weighted | 4.060000|    5| 0.5408102|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0001588| 0.0023214| 0.9487526|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0008824|              0|TRUE                     |    0.2001921|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescClostridiaoTissierellalesfHelcococcaceaegW5053sW5053sp000467935mgs712_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescClostridiaoTissierellalesfHelcococcaceaegW5053sW5053sp000467935mgs712_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescClostridiaoTissierellalesfHelcococcaceaegW5053sW5053sp000467935mgs712_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescClostridiaoTissierellalesfHelcococcaceaegW5053sW5053sp000467935mgs712_against_ebiaGCST90038645chunk8-1.png)
