

# Two sample MR report

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## k__Bacteria|p__Proteobacteria|c__Gammaproteobacteria|o__Enterobacterales|f__Pasteurellaceae|g__Haemophilus|s__Haemophilus_haemolyticus_mgs_2719 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.0515763| 0.0425440| 0.3491711|
|Weighted median           |    4| -0.0030684| 0.0015743| 0.0512947|
|Inverse variance weighted |    4| -0.0033783| 0.0011647| 0.0037239|
|Simple mode               |    4| -0.0030952| 0.0019404| 0.2089507|
|Weighted mode             |    4| -0.0031490| 0.0017169| 0.1640008|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1907118|    2| 0.9090494|
|Inverse variance weighted | 1.4751297|    3| 0.6880222|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0051178| 0.0045158| 0.3746488|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0005213|              0|TRUE                     |    0.3257413|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegHaemophilussHaemophilushaemolyticusmgs2719_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegHaemophilussHaemophilushaemolyticusmgs2719_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegHaemophilussHaemophilushaemolyticusmgs2719_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegHaemophilussHaemophilushaemolyticusmgs2719_against_ebiaGCST90038645chunk8-1.png)
