

# Two sample MR report

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## k__Bacteria|p__Campylobacterota|c__Campylobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter_A|s__unclassified_mgs_1147 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6| -0.0407283| 0.0558941| 0.5065736|
|Weighted median           |    6|  0.0025347| 0.0013713| 0.0645469|
|Inverse variance weighted |    6|  0.0024279| 0.0010806| 0.0246556|
|Simple mode               |    6|  0.0036979| 0.0019107| 0.1107290|
|Weighted mode             |    6|  0.0035025| 0.0017951| 0.1085081|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.9471847|    4| 0.9176959|
|Inverse variance weighted | 1.5435581|    5| 0.9079891|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0045875| 0.0059404| 0.4830585|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000793|              0|TRUE                     |    0.2237037|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapCampylobacterotacCampylobacteriaoCampylobacteralesfCampylobacteraceaegCampylobacterAsunclassifiedmgs1147_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapCampylobacterotacCampylobacteriaoCampylobacteralesfCampylobacteraceaegCampylobacterAsunclassifiedmgs1147_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapCampylobacterotacCampylobacteriaoCampylobacteralesfCampylobacteraceaegCampylobacterAsunclassifiedmgs1147_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapCampylobacterotacCampylobacteriaoCampylobacteralesfCampylobacteraceaegCampylobacterAsunclassifiedmgs1147_against_ebiaGCST90038645chunk8-1.png)
