

# Two sample MR report

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## k__Bacteria|p__Actinobacteriota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Lancefieldella|s__unclassified_mgs_2019 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   13| 0.0051341| 0.0098551| 0.6127183|
|Weighted median           |   13| 0.0004489| 0.0008222| 0.5850825|
|Inverse variance weighted |   13| 0.0012266| 0.0005883| 0.0370674|
|Simple mode               |   13| 0.0000525| 0.0013863| 0.9703935|
|Weighted mode             |   13| 0.0000232| 0.0011764| 0.9845927|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 11.22827|   11| 0.4243426|
|Inverse variance weighted | 11.38933|   12| 0.4958803|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0004313| 0.0010857| 0.6988023|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0021285|              0|TRUE                     |     0.045851|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapActinobacteriotacCoriobacteriiaoCoriobacterialesfAtopobiaceaegLancefieldellasunclassifiedmgs2019_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapActinobacteriotacCoriobacteriiaoCoriobacterialesfAtopobiaceaegLancefieldellasunclassifiedmgs2019_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapActinobacteriotacCoriobacteriiaoCoriobacterialesfAtopobiaceaegLancefieldellasunclassifiedmgs2019_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapActinobacteriotacCoriobacteriiaoCoriobacterialesfAtopobiaceaegLancefieldellasunclassifiedmgs2019_against_ebiaGCST90038645chunk8-1.png)
