

# Two sample MR report

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## k__Bacteria|p__Proteobacteria|c__Gammaproteobacteria|o__Enterobacterales|f__Pasteurellaceae|g__Aggregatibacter|s__unclassified_mgs_2352 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3|  0.0228656| 0.0904391| 0.8423480|
|Weighted median           |    3| -0.0035710| 0.0016227| 0.0277593|
|Inverse variance weighted |    3| -0.0036169| 0.0013271| 0.0064203|
|Simple mode               |    3| -0.0031148| 0.0018246| 0.2299284|
|Weighted mode             |    3| -0.0031199| 0.0015616| 0.1837888|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1121354|    1| 0.7377260|
|Inverse variance weighted | 0.1978984|    2| 0.9057887|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0028419| 0.0097043| 0.8186351|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0006436|              0|TRUE                     |    0.2745871|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegAggregatibactersunclassifiedmgs2352_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegAggregatibactersunclassifiedmgs2352_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegAggregatibactersunclassifiedmgs2352_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegAggregatibactersunclassifiedmgs2352_against_ebiaGCST90038645chunk8-1.png)
