

# Two sample MR report

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## k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Bacteroidaceae|g__Prevotella|s__Prevotella_conceptionensis_mgs_2958 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   11| -0.0087777| 0.0125390| 0.5016003|
|Weighted median           |   11|  0.0015324| 0.0009075| 0.0913039|
|Inverse variance weighted |   11|  0.0015283| 0.0006590| 0.0203901|
|Simple mode               |   11|  0.0023982| 0.0014663| 0.1329846|
|Weighted mode             |   11|  0.0022678| 0.0012901| 0.1092876|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 6.628640|    9| 0.6757202|
|Inverse variance weighted | 7.306057|   10| 0.6962698|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0011339| 0.0013777| 0.4317448|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0016345|              0|TRUE                     |    0.0831853|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfBacteroidaceaegPrevotellasPrevotellaconceptionensismgs2958_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfBacteroidaceaegPrevotellasPrevotellaconceptionensismgs2958_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfBacteroidaceaegPrevotellasPrevotellaconceptionensismgs2958_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfBacteroidaceaegPrevotellasPrevotellaconceptionensismgs2958_against_ebiaGCST90038645chunk8-1.png)
