

# Two sample MR report

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## k__Bacteria|p__Patescibacteria|c__Saccharimonadia|o__Saccharimonadales|f__Saccharimonadaceae|g__unclassified_mgs_2264|s__unclassified_mgs_2264 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    8| 0.0086037| 0.0228717| 0.7197318|
|Weighted median           |    8| 0.0005971| 0.0010760| 0.5789638|
|Inverse variance weighted |    8| 0.0015835| 0.0007865| 0.0440852|
|Simple mode               |    8| 0.0004225| 0.0016736| 0.8079336|
|Weighted mode             |    8| 0.0002527| 0.0014738| 0.8686934|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.273818|    6| 0.6396751|
|Inverse variance weighted | 4.368139|    7| 0.7365318|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0007697| 0.0025062| 0.7691338|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0015571|              0|TRUE                     |    0.0879409|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapPatescibacteriacSaccharimonadiaoSaccharimonadalesfSaccharimonadaceaegunclassifiedmgs2264sunclassifiedmgs2264_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapPatescibacteriacSaccharimonadiaoSaccharimonadalesfSaccharimonadaceaegunclassifiedmgs2264sunclassifiedmgs2264_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapPatescibacteriacSaccharimonadiaoSaccharimonadalesfSaccharimonadaceaegunclassifiedmgs2264sunclassifiedmgs2264_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapPatescibacteriacSaccharimonadiaoSaccharimonadalesfSaccharimonadaceaegunclassifiedmgs2264sunclassifiedmgs2264_against_ebiaGCST90038645chunk8-1.png)
