

# Two sample MR report

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## k__Bacteria|p__Patescibacteria|c__Saccharimonadia|o__Saccharimonadales|f__Saccharimonadaceae|g__unclassified_mgs_1971 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   11| -0.0178841| 0.0212184| 0.4211423|
|Weighted median           |   11|  0.0017231| 0.0009587| 0.0722904|
|Inverse variance weighted |   11|  0.0018582| 0.0007368| 0.0116742|
|Simple mode               |   11|  0.0017004| 0.0011416| 0.1671956|
|Weighted mode             |   11|  0.0016103| 0.0010870| 0.1693110|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.339034|    9| 0.9849037|
|Inverse variance weighted | 3.205785|   10| 0.9761579|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0021701| 0.0023309| 0.3761543|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0017471|              0|TRUE                     |    0.0730832|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapPatescibacteriacSaccharimonadiaoSaccharimonadalesfSaccharimonadaceaegunclassifiedmgs1971_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapPatescibacteriacSaccharimonadiaoSaccharimonadalesfSaccharimonadaceaegunclassifiedmgs1971_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapPatescibacteriacSaccharimonadiaoSaccharimonadalesfSaccharimonadaceaegunclassifiedmgs1971_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapPatescibacteriacSaccharimonadiaoSaccharimonadalesfSaccharimonadaceaegunclassifiedmgs1971_against_ebiaGCST90038645chunk8-1.png)
