

# Two sample MR report

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## k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia_A|s__unclassified_mgs_753 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 0.0074580| 0.0288261| 0.8086170|
|Weighted median           |    6| 0.0015505| 0.0010401| 0.1360257|
|Inverse variance weighted |    6| 0.0016055| 0.0007977| 0.0441581|
|Simple mode               |    6| 0.0003493| 0.0015073| 0.8259493|
|Weighted mode             |    6| 0.0023525| 0.0013577| 0.1436907|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.130936|    4| 0.7116911|
|Inverse variance weighted | 2.172188|    5| 0.8248429|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0006606| 0.0032525| 0.8489659|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0010452|              0|TRUE                     |    0.1639806|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFusobacteriotacFusobacteriiaoFusobacterialesfLeptotrichiaceaegLeptotrichiaAsunclassifiedmgs753_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFusobacteriotacFusobacteriiaoFusobacterialesfLeptotrichiaceaegLeptotrichiaAsunclassifiedmgs753_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFusobacteriotacFusobacteriiaoFusobacterialesfLeptotrichiaceaegLeptotrichiaAsunclassifiedmgs753_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFusobacteriotacFusobacteriiaoFusobacterialesfLeptotrichiaceaegLeptotrichiaAsunclassifiedmgs753_against_ebiaGCST90038645chunk8-1.png)
