

# Two sample MR report

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## k__Bacteria|p__Campylobacterota|c__Campylobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter_A|s__unclassified_mgs_2721 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.0104158| 0.1634976| 0.9532115|
|Weighted median           |    5| -0.0037988| 0.0018866| 0.0440506|
|Inverse variance weighted |    5| -0.0042753| 0.0019437| 0.0278349|
|Simple mode               |    5| -0.0037523| 0.0021787| 0.1601277|
|Weighted mode             |    5| -0.0038737| 0.0016708| 0.0812700|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 7.201433|    3| 0.0657471|
|Inverse variance weighted | 7.204820|    4| 0.1254523|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|        0.000645| 0.0171724| 0.9723976|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0009355|              0|TRUE                     |    0.1875833|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapCampylobacterotacCampylobacteriaoCampylobacteralesfCampylobacteraceaegCampylobacterAsunclassifiedmgs2721_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapCampylobacterotacCampylobacteriaoCampylobacteralesfCampylobacteraceaegCampylobacterAsunclassifiedmgs2721_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapCampylobacterotacCampylobacteriaoCampylobacteralesfCampylobacteraceaegCampylobacterAsunclassifiedmgs2721_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapCampylobacterotacCampylobacteriaoCampylobacteralesfCampylobacteraceaegCampylobacterAsunclassifiedmgs2721_against_ebiaGCST90038645chunk8-1.png)
