

# Two sample MR report

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## k__Bacteria|p__Actinobacteriota|c__Actinobacteria|o__Actinomycetales|f__Actinomycetaceae|g__Pauljensenia|s__Pauljensenia_cellulosilytica_mgs_2826 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.0220935| 0.0268676| 0.5618796|
|Weighted median           |    3| 0.0027880| 0.0013406| 0.0375611|
|Inverse variance weighted |    3| 0.0025049| 0.0011412| 0.0281659|
|Simple mode               |    3| 0.0032654| 0.0017343| 0.2004322|
|Weighted mode             |    3| 0.0031870| 0.0017042| 0.2023925|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.3719416|    1| 0.5419479|
|Inverse variance weighted | 0.9044612|    2| 0.6362074|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|    pval|
|---------------:|---------:|-------:|
|      -0.0022538| 0.0030885| 0.59867|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000516|              0|TRUE                     |    0.3279851|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapActinobacteriotacActinobacteriaoActinomycetalesfActinomycetaceaegPauljenseniasPauljenseniacellulosilyticamgs2826_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapActinobacteriotacActinobacteriaoActinomycetalesfActinomycetaceaegPauljenseniasPauljenseniacellulosilyticamgs2826_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapActinobacteriotacActinobacteriaoActinomycetalesfActinomycetaceaegPauljenseniasPauljenseniacellulosilyticamgs2826_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapActinobacteriotacActinobacteriaoActinomycetalesfActinomycetaceaegPauljenseniasPauljenseniacellulosilyticamgs2826_against_ebiaGCST90038645chunk8-1.png)
