

# Two sample MR report

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## k__Bacteria|p__Proteobacteria|c__Gammaproteobacteria|o__Enterobacterales|f__Pasteurellaceae|g__Aggregatibacter|s__Aggregatibacter_kilianii_B_mgs_1006 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    7|  0.0098786| 0.0147227| 0.5319781|
|Weighted median           |    7| -0.0014689| 0.0010903| 0.1778913|
|Inverse variance weighted |    7| -0.0016755| 0.0008230| 0.0417578|
|Simple mode               |    7| -0.0017350| 0.0013133| 0.2346111|
|Weighted mode             |    7| -0.0013834| 0.0011811| 0.2858664|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.100719|    5| 0.5350079|
|Inverse variance weighted | 4.718535|    6| 0.5803860|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0013175| 0.0016762| 0.4674571|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0011258|              0|TRUE                     |    0.1492262|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegAggregatibactersAggregatibacterkilianiiBmgs1006_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegAggregatibactersAggregatibacterkilianiiBmgs1006_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegAggregatibactersAggregatibacterkilianiiBmgs1006_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapProteobacteriacGammaproteobacteriaoEnterobacteralesfPasteurellaceaegAggregatibactersAggregatibacterkilianiiBmgs1006_against_ebiaGCST90038645chunk8-1.png)
