

# Two sample MR report

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## k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Flavobacteriales|f__Weeksellaceae|g__unclassified_mgs_791|s__unclassified_mgs_791 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6|  0.0128186| 0.0708885| 0.8652955|
|Weighted median           |    6| -0.0017069| 0.0013270| 0.1983319|
|Inverse variance weighted |    6| -0.0023309| 0.0011157| 0.0366905|
|Simple mode               |    6| -0.0013121| 0.0017369| 0.4840383|
|Weighted mode             |    6| -0.0017105| 0.0015365| 0.3162501|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 6.054612|    4| 0.1951068|
|Inverse variance weighted | 6.123764|    5| 0.2943618|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0016119| 0.0075412| 0.8412017|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0007907|              0|TRUE                     |    0.2258023|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapBacteroidotacBacteroidiaoFlavobacterialesfWeeksellaceaegunclassifiedmgs791sunclassifiedmgs791_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapBacteroidotacBacteroidiaoFlavobacterialesfWeeksellaceaegunclassifiedmgs791sunclassifiedmgs791_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapBacteroidotacBacteroidiaoFlavobacterialesfWeeksellaceaegunclassifiedmgs791sunclassifiedmgs791_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapBacteroidotacBacteroidiaoFlavobacterialesfWeeksellaceaegunclassifiedmgs791sunclassifiedmgs791_against_ebiaGCST90038645chunk8-1.png)
