

# Two sample MR report

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## k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Bacteroidaceae|g__Prevotella|s__Prevotella_multisaccharivorax_mgs_669 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.0119062| 0.0270509| 0.6896168|
|Weighted median           |    5|  0.0020832| 0.0011439| 0.0685978|
|Inverse variance weighted |    5|  0.0024049| 0.0008357| 0.0040075|
|Simple mode               |    5|  0.0019058| 0.0016234| 0.3055386|
|Weighted mode             |    5|  0.0013806| 0.0015537| 0.4244324|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.638014|    3| 0.4508641|
|Inverse variance weighted | 2.918167|    4| 0.5716120|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0015439| 0.0029168| 0.6332659|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0006775|              0|TRUE                     |     0.263157|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfBacteroidaceaegPrevotellasPrevotellamultisaccharivoraxmgs669_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfBacteroidaceaegPrevotellasPrevotellamultisaccharivoraxmgs669_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfBacteroidaceaegPrevotellasPrevotellamultisaccharivoraxmgs669_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapBacteroidotacBacteroidiaoBacteroidalesfBacteroidaceaegPrevotellasPrevotellamultisaccharivoraxmgs669_against_ebiaGCST90038645chunk8-1.png)
