

# Two sample MR report

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## k__Bacteria|p__Firmicutes|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Granulicatella|s__unclassified_mgs_3146 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.0166398| 0.0136010| 0.3457481|
|Weighted median           |    4| -0.0016963| 0.0011716| 0.1476577|
|Inverse variance weighted |    4| -0.0018847| 0.0009595| 0.0494998|
|Simple mode               |    4| -0.0009456| 0.0016176| 0.5999073|
|Weighted mode             |    4| -0.0009456| 0.0015365| 0.5818276|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.2935323|    2| 0.8634959|
|Inverse variance weighted | 1.4763327|    3| 0.6877434|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0016276| 0.0014965| 0.3903915|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0006049|              0|TRUE                     |    0.2887829|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescBacillioLactobacillalesfAerococcaceaegGranulicatellasunclassifiedmgs3146_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescBacillioLactobacillalesfAerococcaceaegGranulicatellasunclassifiedmgs3146_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescBacillioLactobacillalesfAerococcaceaegGranulicatellasunclassifiedmgs3146_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescBacillioLactobacillalesfAerococcaceaegGranulicatellasunclassifiedmgs3146_against_ebiaGCST90038645chunk8-1.png)
