

# Two sample MR report

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## k__Bacteria|p__Firmicutes|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Catonella|s__unclassified_mgs_3459 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3|  0.0504347| 0.0467215| 0.4756809|
|Weighted median           |    3| -0.0019721| 0.0015020| 0.1891862|
|Inverse variance weighted |    3| -0.0032287| 0.0011407| 0.0046470|
|Simple mode               |    3| -0.0019148| 0.0020538| 0.4496021|
|Weighted mode             |    3| -0.0018371| 0.0016381| 0.3786363|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 0.469368|    1| 0.4932781|
|Inverse variance weighted | 1.789392|    2| 0.4087318|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       -0.005932| 0.0051631| 0.4559519|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004386|              0|TRUE                     |    0.3669304|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescClostridiaoLachnospiralesfLachnospiraceaegCatonellasunclassifiedmgs3459_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescClostridiaoLachnospiralesfLachnospiraceaegCatonellasunclassifiedmgs3459_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescClostridiaoLachnospiralesfLachnospiraceaegCatonellasunclassifiedmgs3459_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescClostridiaoLachnospiralesfLachnospiraceaegCatonellasunclassifiedmgs3459_against_ebiaGCST90038645chunk8-1.png)
