

# Two sample MR report

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## k__Bacteria|p__Patescibacteria|c__Saccharimonadia|o__Saccharimonadales|f__Saccharimonadaceae|g__unclassified_mgs_3574|s__unclassified_mgs_3574 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    7| 0.0108942| 0.0519867| 0.8422845|
|Weighted median           |    7| 0.0031183| 0.0010493| 0.0029599|
|Inverse variance weighted |    7| 0.0026338| 0.0008450| 0.0018263|
|Simple mode               |    7| 0.0034292| 0.0016355| 0.0808470|
|Weighted mode             |    7| 0.0034051| 0.0016380| 0.0828733|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 7.320259|    5| 0.1978908|
|Inverse variance weighted | 7.357234|    6| 0.2890696|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0008987| 0.0056549| 0.8799531|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0009913|              0|TRUE                     |    0.1839058|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapPatescibacteriacSaccharimonadiaoSaccharimonadalesfSaccharimonadaceaegunclassifiedmgs3574sunclassifiedmgs3574_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapPatescibacteriacSaccharimonadiaoSaccharimonadalesfSaccharimonadaceaegunclassifiedmgs3574sunclassifiedmgs3574_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapPatescibacteriacSaccharimonadiaoSaccharimonadalesfSaccharimonadaceaegunclassifiedmgs3574sunclassifiedmgs3574_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapPatescibacteriacSaccharimonadiaoSaccharimonadalesfSaccharimonadaceaegunclassifiedmgs3574sunclassifiedmgs3574_against_ebiaGCST90038645chunk8-1.png)
