

# Two sample MR report

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## k__Bacteria|p__Firmicutes|c__Bacilli|o__Erysipelotrichales|f__Erysipelotrichaceae|g__Solobacterium|s__unclassified_mgs_3577 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.0139850| 0.0458068| 0.7889784|
|Weighted median           |    4|  0.0024085| 0.0013858| 0.0822267|
|Inverse variance weighted |    4|  0.0028902| 0.0011726| 0.0137129|
|Simple mode               |    4|  0.0026137| 0.0015712| 0.1948093|
|Weighted mode             |    4|  0.0023255| 0.0013674| 0.1875658|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.951649|    2| 0.2285901|
|Inverse variance weighted | 3.152131|    3| 0.3687591|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0018202| 0.0049386| 0.7478059|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0006827|              0|TRUE                     |     0.259976|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescBacillioErysipelotrichalesfErysipelotrichaceaegSolobacteriumsunclassifiedmgs3577_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescBacillioErysipelotrichalesfErysipelotrichaceaegSolobacteriumsunclassifiedmgs3577_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescBacillioErysipelotrichalesfErysipelotrichaceaegSolobacteriumsunclassifiedmgs3577_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescBacillioErysipelotrichalesfErysipelotrichaceaegSolobacteriumsunclassifiedmgs3577_against_ebiaGCST90038645chunk8-1.png)
