

# Two sample MR report

---

## k__Bacteria|p__Spirochaetota|c__Spirochaetia|o__Treponematales|f__Treponemataceae|g__unclassified_mgs_874 against ebi-a-GCST90038645

Date: **14 February, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    5| -0.0148005| 0.0192113| 0.4971676|
|Weighted median           |    5| -0.0036577| 0.0012075| 0.0024521|
|Inverse variance weighted |    5| -0.0036845| 0.0008994| 0.0000420|
|Simple mode               |    5| -0.0036931| 0.0017553| 0.1031935|
|Weighted mode             |    5| -0.0036409| 0.0015994| 0.0851219|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.027579|    3| 0.3873926|
|Inverse variance weighted | 3.366209|    4| 0.4985109|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0012832| 0.0022152| 0.6030435|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0008859|              0|TRUE                     |    0.2014034|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapSpirochaetotacSpirochaetiaoTreponematalesfTreponemataceaegunclassifiedmgs874_against_ebiaGCST90038645chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapSpirochaetotacSpirochaetiaoTreponematalesfTreponemataceaegunclassifiedmgs874_against_ebiaGCST90038645chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/kBacteriapSpirochaetotacSpirochaetiaoTreponematalesfTreponemataceaegunclassifiedmgs874_against_ebiaGCST90038645chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapSpirochaetotacSpirochaetiaoTreponematalesfTreponemataceaegunclassifiedmgs874_against_ebiaGCST90038645chunk8-1.png)
