

# Two sample MR report

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## k__Bacteria|p__Firmicutes|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__F0422|s__unclassified_mgs_2103 against ebi-a-GCST90038645

Date: **14 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    9| -0.0195163| 0.0225803| 0.4160508|
|Weighted median           |    9| -0.0018690| 0.0009473| 0.0484947|
|Inverse variance weighted |    9| -0.0015429| 0.0007357| 0.0359663|
|Simple mode               |    9| -0.0022153| 0.0012614| 0.1171174|
|Weighted mode             |    9| -0.0019503| 0.0011498| 0.1282954|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 5.222040|    7| 0.6328869|
|Inverse variance weighted | 5.856293|    8| 0.6633254|

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### Test for directional horizontal pleiotropy


| egger_intercept|      se|      pval|
|---------------:|-------:|---------:|
|       0.0019432| 0.00244| 0.4519591|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0013444|              0|TRUE                     |    0.1146295|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/kBacteriapFirmicutescNegativicutesoVeillonellalesfVeillonellaceaegF0422sunclassifiedmgs2103_against_ebiaGCST90038645chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/kBacteriapFirmicutescNegativicutesoVeillonellalesfVeillonellaceaegF0422sunclassifiedmgs2103_against_ebiaGCST90038645chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/kBacteriapFirmicutescNegativicutesoVeillonellalesfVeillonellaceaegF0422sunclassifiedmgs2103_against_ebiaGCST90038645chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/kBacteriapFirmicutescNegativicutesoVeillonellalesfVeillonellaceaegF0422sunclassifiedmgs2103_against_ebiaGCST90038645chunk8-1.png)
