Two sample MR report
k__Bacteria|p__Firmicutes|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__unclassified_mgs_1034 against ebi-a-GCST90038645
Date: 14 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.0273960 | 0.0263264 | 0.3745407 |
| Weighted median | 5 | 0.0024958 | 0.0012550 | 0.0467273 |
| Inverse variance weighted | 5 | 0.0024637 | 0.0009363 | 0.0085091 |
| Simple mode | 5 | 0.0032340 | 0.0016079 | 0.1146197 |
| Weighted mode | 5 | 0.0029564 | 0.0014031 | 0.1028408 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.1755093 | 3 | 0.9814426 |
| Inverse variance weighted | 1.4635777 | 4 | 0.8330730 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0032262 | 0.0028426 | 0.3388805 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0011529 | 0 | TRUE | 0.1430129 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
