Two sample MR report
k__Bacteria|p__Firmicutes|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__unclassified_mgs_2388 against ebi-a-GCST90038645
Date: 14 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.0041555 | 0.0782435 | 0.9662211 |
| Weighted median | 3 | -0.0034285 | 0.0019865 | 0.0843662 |
| Inverse variance weighted | 3 | -0.0034185 | 0.0017028 | 0.0446953 |
| Simple mode | 3 | -0.0034377 | 0.0023892 | 0.2868060 |
| Weighted mode | 3 | -0.0034270 | 0.0020861 | 0.2421367 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0048658 | 1 | 0.9443887 |
| Inverse variance weighted | 0.0049545 | 2 | 0.9975258 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 8.2e-05 | 0.0087059 | 0.994002 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0005763 | 0 | TRUE | 0.3007164 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
