Two sample MR report
k__Bacteria|p__Firmicutes|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__unclassified_mgs_121|s__unclassified_mgs_121 against ebi-a-GCST90038645
Date: 14 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | -0.1049310 | 0.0468105 | 0.0884637 |
| Weighted median | 6 | -0.0015017 | 0.0013488 | 0.2655616 |
| Inverse variance weighted | 6 | -0.0022995 | 0.0009988 | 0.0213250 |
| Simple mode | 6 | -0.0000367 | 0.0021729 | 0.9871639 |
| Weighted mode | 6 | -0.0038757 | 0.0017576 | 0.0785856 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.2145646 | 4 | 0.9946407 |
| Inverse variance weighted | 5.0237530 | 5 | 0.4129882 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0110351 | 0.005032 | 0.0933803 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0008749 | 0 | TRUE | 0.2022438 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
