Two sample MR report
k__Bacteria|p__Firmicutes|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus_sanguinis_mgs_3170 against ebi-a-GCST90038645
Date: 14 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | 0.0069613 | 0.0504713 | 0.8956818 |
| Weighted median | 7 | 0.0002855 | 0.0013224 | 0.8290637 |
| Inverse variance weighted | 7 | 0.0020399 | 0.0009879 | 0.0389324 |
| Simple mode | 7 | 0.0001537 | 0.0019174 | 0.9387184 |
| Weighted mode | 7 | 0.0001537 | 0.0017197 | 0.9316966 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 6.987967 | 5 | 0.2215367 |
| Inverse variance weighted | 7.001261 | 6 | 0.3207306 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0005237 | 0.0053698 | 0.9260942 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0010939 | 0 | TRUE | 0.1535222 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
