Two sample MR report
k__Bacteria|p__Firmicutes|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__unclassified_mgs_2358 against ebi-a-GCST90038645
Date: 14 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | -0.0568886 | 0.0487139 | 0.3077438 |
| Weighted median | 6 | 0.0018351 | 0.0013766 | 0.1824999 |
| Inverse variance weighted | 6 | 0.0028033 | 0.0014174 | 0.0479513 |
| Simple mode | 6 | -0.0001048 | 0.0030593 | 0.9740024 |
| Weighted mode | 6 | -0.0002638 | 0.0029163 | 0.9314275 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 8.815964 | 4 | 0.0658678 |
| Inverse variance weighted | 12.127812 | 5 | 0.0330778 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0065715 | 0.0053608 | 0.2874972 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0010392 | 0 | TRUE | 0.1651952 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
