Two sample MR report
k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia|s__unclassified_mgs_227 against ebi-a-GCST90038645
Date: 14 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | -0.0561524 | 0.0613530 | 0.4118512 |
| Weighted median | 6 | 0.0024064 | 0.0012328 | 0.0509340 |
| Inverse variance weighted | 6 | 0.0023161 | 0.0009526 | 0.0150457 |
| Simple mode | 6 | 0.0024816 | 0.0015505 | 0.1703866 |
| Weighted mode | 6 | 0.0024816 | 0.0014169 | 0.1402652 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.020870 | 4 | 0.9066152 |
| Inverse variance weighted | 1.929269 | 5 | 0.8588430 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0064112 | 0.0067267 | 0.3945114 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0008905 | 0 | TRUE | 0.1984381 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
