Two sample MR report
k__Bacteria|p__Firmicutes|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__Streptococcus_mitis_AR_mgs_500 against ebi-a-GCST90038645
Date: 14 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.0218852 | 0.0262345 | 0.4653709 |
| Weighted median | 5 | 0.0013770 | 0.0011153 | 0.2169778 |
| Inverse variance weighted | 5 | 0.0018783 | 0.0009225 | 0.0417440 |
| Simple mode | 5 | 0.0020638 | 0.0014086 | 0.2167358 |
| Weighted mode | 5 | 0.0018304 | 0.0013201 | 0.2378566 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.105418 | 3 | 0.5508173 |
| Inverse variance weighted | 2.926930 | 4 | 0.5701270 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0025132 | 0.0027728 | 0.4315552 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0008919 | 0 | TRUE | 0.196446 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
