Two sample MR report
k__Bacteria|p__Firmicutes|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__unclassified_mgs_1680 against ebi-a-GCST90038645
Date: 14 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | -0.0685748 | 0.0820184 | 0.4412165 |
| Weighted median | 7 | 0.0013943 | 0.0010675 | 0.1915213 |
| Inverse variance weighted | 7 | 0.0018527 | 0.0007941 | 0.0196402 |
| Simple mode | 7 | 0.0008255 | 0.0015463 | 0.6126184 |
| Weighted mode | 7 | 0.0010420 | 0.0013351 | 0.4647731 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4.327440 | 5 | 0.5032977 |
| Inverse variance weighted | 5.064839 | 6 | 0.5355243 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0074394 | 0.0086633 | 0.4297302 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0010469 | 0 | TRUE | 0.1635589 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
