Two sample MR report
k__Bacteria|p__Firmicutes|c__Clostridia|o__Tissierellales|f__Helcococcaceae|g__W5053|s__W5053_sp000467935_mgs_712 against ebi-a-GCST90038645
Date: 14 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.0004772 | 0.0213090 | 0.9832049 |
| Weighted median | 6 | 0.0020934 | 0.0010840 | 0.0534662 |
| Inverse variance weighted | 6 | 0.0019336 | 0.0008147 | 0.0176187 |
| Simple mode | 6 | 0.0026061 | 0.0015642 | 0.1565638 |
| Weighted mode | 6 | 0.0022272 | 0.0015250 | 0.2039927 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4.055257 | 4 | 0.3985792 |
| Inverse variance weighted | 4.060000 | 5 | 0.5408102 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0001588 | 0.0023214 | 0.9487526 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0008824 | 0 | TRUE | 0.2001921 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
