Two sample MR report
k__Bacteria|p__Firmicutes|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__unclassified_mgs_1587 against ebi-a-GCST90038645
Date: 14 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | -0.0014717 | 0.0440429 | 0.9744281 |
| Weighted median | 8 | 0.0015860 | 0.0010250 | 0.1218089 |
| Inverse variance weighted | 8 | 0.0018772 | 0.0008080 | 0.0201653 |
| Simple mode | 8 | 0.0020744 | 0.0012178 | 0.1322812 |
| Weighted mode | 8 | 0.0017892 | 0.0011895 | 0.1762479 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4.715835 | 6 | 0.5807411 |
| Inverse variance weighted | 4.721618 | 7 | 0.6938923 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0003545 | 0.0046619 | 0.9418519 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0010539 | 0 | TRUE | 0.1621782 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
