Two sample MR report
k__Bacteria|p__Firmicutes|c__Bacilli|o__Staphylococcales|f__Gemellaceae|g__Gemella|s__unclassified_mgs_2041 against ebi-a-GCST90038645
Date: 14 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.0103920 | 0.0130787 | 0.4713422 |
| Weighted median | 6 | 0.0020808 | 0.0011115 | 0.0611904 |
| Inverse variance weighted | 6 | 0.0019568 | 0.0008790 | 0.0260022 |
| Simple mode | 6 | 0.0025848 | 0.0016601 | 0.1801972 |
| Weighted mode | 6 | 0.0022509 | 0.0015463 | 0.2052410 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.073036 | 4 | 0.7223275 |
| Inverse variance weighted | 2.490896 | 5 | 0.7778656 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0009444 | 0.001461 | 0.5532265 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0010006 | 0 | TRUE | 0.1723334 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
