Two sample MR report
k__Bacteria|p__Firmicutes|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Catonella|s__unclassified_mgs_3459 against ebi-a-GCST90038645
Date: 14 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.0504347 | 0.0467215 | 0.4756809 |
| Weighted median | 3 | -0.0019721 | 0.0015020 | 0.1891862 |
| Inverse variance weighted | 3 | -0.0032287 | 0.0011407 | 0.0046470 |
| Simple mode | 3 | -0.0019148 | 0.0020538 | 0.4496021 |
| Weighted mode | 3 | -0.0018371 | 0.0016381 | 0.3786363 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.469368 | 1 | 0.4932781 |
| Inverse variance weighted | 1.789392 | 2 | 0.4087318 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.005932 | 0.0051631 | 0.4559519 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004386 | 0 | TRUE | 0.3669304 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
