Two sample MR report
k__Bacteria|p__Spirochaetota|c__Spirochaetia|o__Treponematales|f__Treponemataceae|g__unclassified_mgs_874 against ebi-a-GCST90038645
Date: 14 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.0148005 | 0.0192113 | 0.4971676 |
| Weighted median | 5 | -0.0036577 | 0.0012075 | 0.0024521 |
| Inverse variance weighted | 5 | -0.0036845 | 0.0008994 | 0.0000420 |
| Simple mode | 5 | -0.0036931 | 0.0017553 | 0.1031935 |
| Weighted mode | 5 | -0.0036409 | 0.0015994 | 0.0851219 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3.027579 | 3 | 0.3873926 |
| Inverse variance weighted | 3.366209 | 4 | 0.4985109 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0012832 | 0.0022152 | 0.6030435 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0008859 | 0 | TRUE | 0.2014034 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
