Two sample MR report
k__Bacteria|p__Actinobacteriota|c__Actinobacteria|o__Actinomycetales|f__Actinomycetaceae|g__Pauljensenia|s__unclassified_mgs_1959 against ebi-a-GCST90038645
Date: 14 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.2997132 | 0.2457297 | 0.4371971 |
| Weighted median | 3 | 0.0035960 | 0.0023200 | 0.1211505 |
| Inverse variance weighted | 3 | 0.0041142 | 0.0020037 | 0.0400456 |
| Simple mode | 3 | 0.0038111 | 0.0037836 | 0.4198618 |
| Weighted mode | 3 | 0.0035643 | 0.0022157 | 0.2489602 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0072396 | 1 | 0.9321931 |
| Inverse variance weighted | 1.5360981 | 2 | 0.4639173 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0336633 | 0.0272253 | 0.432937 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0005908 | 0 | TRUE | 0.2946144 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
