Two sample MR report
k__Bacteria|p__Patescibacteria|c__Saccharimonadia|o__Saccharimonadales|f__Saccharimonadaceae|g__unclassified_mgs_549|s__unclassified_mgs_549 against ebi-a-GCST90038645
Date: 14 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.0102620 | 0.1490685 | 0.9484204 |
| Weighted median | 6 | -0.0027429 | 0.0013071 | 0.0358672 |
| Inverse variance weighted | 6 | -0.0022990 | 0.0010868 | 0.0343990 |
| Simple mode | 6 | -0.0037911 | 0.0022007 | 0.1455518 |
| Weighted mode | 6 | -0.0035751 | 0.0021497 | 0.1571882 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 6.107370 | 4 | 0.1912720 |
| Inverse variance weighted | 6.118212 | 5 | 0.2948858 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0013354 | 0.0158472 | 0.9368938 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0007858 | 0 | TRUE | 0.2315241 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
