Two sample MR report
k__Bacteria|p__Proteobacteria|c__Gammaproteobacteria|o__Enterobacterales|f__Pasteurellaceae|g__Haemophilus|s__unclassified_mgs_2527 against ebi-a-GCST90038645
Date: 14 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | 0.0603242 | 0.1128129 | 0.6299312 |
| Weighted median | 5 | -0.0027214 | 0.0013331 | 0.0412019 |
| Inverse variance weighted | 5 | -0.0029933 | 0.0010476 | 0.0042720 |
| Simple mode | 5 | -0.0026100 | 0.0018395 | 0.2289316 |
| Weighted mode | 5 | -0.0024698 | 0.0019291 | 0.2696437 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.682279 | 3 | 0.6408807 |
| Inverse variance weighted | 1.997320 | 4 | 0.7362518 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0067286 | 0.0119879 | 0.6138002 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0006481 | 0 | TRUE | 0.2735009 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
