Two sample MR report
k__Bacteria|p__Proteobacteria|c__Gammaproteobacteria|o__Enterobacterales|f__Pasteurellaceae|g__Aggregatibacter|s__Aggregatibacter_kilianii_B_mgs_1006 against ebi-a-GCST90038645
Date: 14 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | 0.0098786 | 0.0147227 | 0.5319781 |
| Weighted median | 7 | -0.0014689 | 0.0010903 | 0.1778913 |
| Inverse variance weighted | 7 | -0.0016755 | 0.0008230 | 0.0417578 |
| Simple mode | 7 | -0.0017350 | 0.0013133 | 0.2346111 |
| Weighted mode | 7 | -0.0013834 | 0.0011811 | 0.2858664 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4.100719 | 5 | 0.5350079 |
| Inverse variance weighted | 4.718535 | 6 | 0.5803860 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0013175 | 0.0016762 | 0.4674571 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0011258 | 0 | TRUE | 0.1492262 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
