Two sample MR report
k__Bacteria|p__Spirochaetota|c__Spirochaetia|o__Treponematales|f__Treponemataceae|g__Treponema_A|s__unclassified_mgs_35 against ebi-a-GCST90038645
Date: 14 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | 0.0466795 | 0.0297752 | 0.1777295 |
| Weighted median | 7 | -0.0019348 | 0.0010551 | 0.0667004 |
| Inverse variance weighted | 7 | -0.0016423 | 0.0007724 | 0.0334832 |
| Simple mode | 7 | -0.0016765 | 0.0015363 | 0.3170219 |
| Weighted mode | 7 | -0.0016498 | 0.0014224 | 0.2901480 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.37947 | 5 | 0.7945275 |
| Inverse variance weighted | 5.01501 | 6 | 0.5418894 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0051057 | 0.003145 | 0.165424 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0010838 | 0 | TRUE | 0.1555831 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
