Two sample MR report
k__Bacteria|p__Proteobacteria|c__Gammaproteobacteria|o__Enterobacterales|f__Pasteurellaceae|g__Aggregatibacter|s__Aggregatibacter_sp000466335_mgs_2558 against ebi-a-GCST90038645
Date: 14 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.0526793 | 0.0486087 | 0.3578042 |
| Weighted median | 5 | -0.0021736 | 0.0013797 | 0.1151649 |
| Inverse variance weighted | 5 | -0.0020942 | 0.0010292 | 0.0418727 |
| Simple mode | 5 | -0.0026755 | 0.0017683 | 0.2048260 |
| Weighted mode | 5 | -0.0022948 | 0.0018178 | 0.2753938 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.817595 | 3 | 0.6111136 |
| Inverse variance weighted | 2.901049 | 4 | 0.5745188 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.005335 | 0.0051254 | 0.3744372 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000656 | 0 | TRUE | 0.270204 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
