Two sample MR report
k__Bacteria|p__Proteobacteria|c__Gammaproteobacteria|o__Enterobacterales|f__Pasteurellaceae|g__Aggregatibacter|s__Aggregatibacter_sp000466335_mgs_2597 against ebi-a-GCST90038645
Date: 14 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | 0.0488727 | 0.0490212 | 0.3922566 |
| Weighted median | 5 | 0.0029576 | 0.0013919 | 0.0335975 |
| Inverse variance weighted | 5 | 0.0022164 | 0.0010954 | 0.0430448 |
| Simple mode | 5 | 0.0032302 | 0.0021939 | 0.2148987 |
| Weighted mode | 5 | 0.0035456 | 0.0019224 | 0.1388941 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3.405521 | 3 | 0.3332240 |
| Inverse variance weighted | 4.434337 | 4 | 0.3504045 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0050924 | 0.0053491 | 0.4113293 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000724 | 0 | TRUE | 0.2467699 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
