Two sample MR report
k__Bacteria|p__Firmicutes|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus|s__unclassified_mgs_1512 against ebi-a-GCST90038645
Date: 14 February, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.1597513 | 0.1469867 | 0.4735230 |
| Weighted median | 3 | -0.0018003 | 0.0014467 | 0.2133552 |
| Inverse variance weighted | 3 | -0.0022873 | 0.0011242 | 0.0418836 |
| Simple mode | 3 | -0.0008535 | 0.0019657 | 0.7064913 |
| Weighted mode | 3 | -0.0009843 | 0.0018603 | 0.6495926 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.8136996 | 1 | 0.3670287 |
| Inverse variance weighted | 1.9614083 | 2 | 0.3750469 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0168086 | 0.0156898 | 0.4780909 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004272 | 0 | TRUE | 0.3729767 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
