

# Two sample MR report

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## phenotype against L

Date: **25 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|     b|    se|  pval|
|:-------------------------|----:|-----:|-----:|-----:|
|MR Egger                  |  164| 0.067| 0.209| 0.749|
|Weighted median           |  164| 0.189| 0.087| 0.030|
|Inverse variance weighted |  164| 0.303| 0.074| 0.000|
|Simple mode               |  164| 0.118| 0.245| 0.630|
|Weighted mode             |  164| 0.063| 0.135| 0.643|

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### Heterogeneity tests


|method                    |   Q| Q_df| Q_pval|
|:-------------------------|---:|----:|------:|
|MR Egger                  | 344|  162|      0|
|Inverse variance weighted | 347|  163|      0|

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### Test for directional horizontal pleiotropy


| egger_intercept|    se| pval|
|---------------:|-----:|----:|
|           0.004| 0.004| 0.23|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|               0|              0|TRUE                     |        0.021|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/phenotype_against_Lchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/phenotype_against_Lchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/phenotype_against_Lchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/phenotype_against_Lchunk8-1.png)
