Two sample MR report
phenotype against L
Date: 25 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 164 | 0.067 | 0.209 | 0.749 |
| Weighted median | 164 | 0.189 | 0.087 | 0.030 |
| Inverse variance weighted | 164 | 0.303 | 0.074 | 0.000 |
| Simple mode | 164 | 0.118 | 0.245 | 0.630 |
| Weighted mode | 164 | 0.063 | 0.135 | 0.643 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 344 | 162 | 0 |
| Inverse variance weighted | 347 | 163 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.004 | 0.004 | 0.23 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.021 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
