Two sample MR report
Medication use (drugs used in diabetes) || id:ebi-a-GCST90018761 against Pancreatic hormone || id:prot-a-2352
Date: 01 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 86 | -0.003 | 0.089 | 0.976 |
| Weighted median | 86 | 0.009 | 0.060 | 0.881 |
| Inverse variance weighted | 86 | -0.054 | 0.038 | 0.154 |
| Simple mode | 86 | 0.100 | 0.119 | 0.402 |
| Weighted mode | 86 | 0.045 | 0.068 | 0.514 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 93.8 | 84 | 0.217 |
| Inverse variance weighted | 94.3 | 85 | 0.230 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.005 | 0.009 | 0.526 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | FALSE | 0.93 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
