Two sample MR report
Pancreatic cancer || id:bbj-a-140 against Type 2 diabetes || id:ebi-a-GCST90018706
Date: 26 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | 0.014 | 0.035 | 0.711 |
| Weighted median | 5 | -0.008 | 0.016 | 0.607 |
| Inverse variance weighted | 5 | -0.005 | 0.012 | 0.667 |
| Simple mode | 5 | -0.020 | 0.024 | 0.456 |
| Weighted mode | 5 | -0.021 | 0.023 | 0.420 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3.69 | 3 | 0.296 |
| Inverse variance weighted | 4.13 | 4 | 0.389 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.01 | 0.016 | 0.594 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.891 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
