Two sample MR report
Pancreatic cancer || id:ebi-a-GCST90018893 against Type 2 diabetes || id:ebi-a-GCST90018926
Date: 26 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 19 | 0.023 | 0.020 | 0.283 |
| Weighted median | 19 | 0.015 | 0.013 | 0.250 |
| Inverse variance weighted | 19 | 0.010 | 0.010 | 0.287 |
| Simple mode | 19 | 0.018 | 0.025 | 0.496 |
| Weighted mode | 19 | 0.018 | 0.026 | 0.492 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 20.0 | 17 | 0.272 |
| Inverse variance weighted | 20.6 | 18 | 0.300 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.004 | 0.006 | 0.497 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.92 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
