Two sample MR report
Type 2 diabetes || id:bbj-a-153 against Colorectal cancer || id:bbj-a-107
Date: 01 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 109 | -0.147 | 0.057 | 0.012 |
| Weighted median | 109 | -0.136 | 0.039 | 0.001 |
| Inverse variance weighted | 109 | -0.142 | 0.024 | 0.000 |
| Simple mode | 109 | -0.169 | 0.075 | 0.026 |
| Weighted mode | 109 | -0.150 | 0.050 | 0.004 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 113 | 107 | 0.327 |
| Inverse variance weighted | 113 | 108 | 0.351 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0 | 0.005 | 0.922 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.007 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
