Two sample MR report
Type 2 diabetes || id:bbj-a-153 against Pancreatic cancer || id:bbj-a-140
Date: 01 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 109 | 0.740 | 0.254 | 0.004 |
| Weighted median | 109 | 0.289 | 0.157 | 0.065 |
| Inverse variance weighted | 109 | 0.186 | 0.108 | 0.086 |
| Simple mode | 109 | 0.407 | 0.392 | 0.301 |
| Weighted mode | 109 | 0.294 | 0.216 | 0.176 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 147 | 107 | 0.006 |
| Inverse variance weighted | 155 | 108 | 0.002 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.052 | 0.022 | 0.018 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.007 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
