Two sample MR report
Type 2 diabetes || id:bbj-a-153 against hepatocellular carcinoma || id:bbj-a-158
Date: 02 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 109 | -0.181 | 0.125 | 0.149 |
| Weighted median | 109 | -0.075 | 0.075 | 0.316 |
| Inverse variance weighted | 109 | -0.089 | 0.052 | 0.088 |
| Simple mode | 109 | -0.069 | 0.162 | 0.670 |
| Weighted mode | 109 | -0.098 | 0.102 | 0.341 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 147 | 107 | 0.007 |
| Inverse variance weighted | 148 | 108 | 0.007 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.009 | 0.011 | 0.415 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.007 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
