Two sample MR report
Type 2 diabetes || id:ebi-a-GCST90018706 against Alcohol-related hepatocellular carcinoma || id:ebi-a-GCST90092003
Date: 02 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 88 | 0.278 | 0.214 | 0.199 |
| Weighted median | 88 | 0.063 | 0.159 | 0.693 |
| Inverse variance weighted | 88 | 0.088 | 0.097 | 0.366 |
| Simple mode | 88 | -0.224 | 0.295 | 0.449 |
| Weighted mode | 88 | 0.117 | 0.206 | 0.573 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 90 | 86 | 0.363 |
| Inverse variance weighted | 91 | 87 | 0.363 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.021 | 0.021 | 0.323 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | FALSE | 0.958 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
