Two sample MR report
Type 2 diabetes || id:ebi-a-GCST90018706 against Colorectal cancer || id:ebi-a-GCST90018588
Date: 01 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 105 | -0.103 | 0.055 | 0.065 |
| Weighted median | 105 | -0.139 | 0.036 | 0.000 |
| Inverse variance weighted | 105 | -0.126 | 0.023 | 0.000 |
| Simple mode | 105 | -0.116 | 0.072 | 0.107 |
| Weighted mode | 105 | -0.126 | 0.046 | 0.007 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 127 | 103 | 0.052 |
| Inverse variance weighted | 128 | 104 | 0.058 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.002 | 0.005 | 0.657 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.043 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
