Two sample MR report
Type 2 diabetes || id:ebi-a-GCST90018706 against Colorectal cancer || id:ebi-a-GCST90018808
Date: 01 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 104 | -0.071 | 0.036 | 0.052 |
| Weighted median | 104 | -0.084 | 0.023 | 0.000 |
| Inverse variance weighted | 104 | -0.073 | 0.016 | 0.000 |
| Simple mode | 104 | -0.116 | 0.043 | 0.008 |
| Weighted mode | 104 | -0.089 | 0.028 | 0.002 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 120 | 102 | 0.109 |
| Inverse variance weighted | 120 | 103 | 0.122 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0 | 0.004 | 0.939 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.012 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
