Two sample MR report
Type 2 diabetes || id:ebi-a-GCST90018706 against Pancreatic cancer || id:bbj-a-140
Date: 01 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 101 | 0.536 | 0.224 | 0.018 |
| Weighted median | 101 | 0.122 | 0.152 | 0.423 |
| Inverse variance weighted | 101 | 0.122 | 0.097 | 0.208 |
| Simple mode | 101 | -0.008 | 0.343 | 0.981 |
| Weighted mode | 101 | 0.162 | 0.180 | 0.370 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 118 | 99 | 0.091 |
| Inverse variance weighted | 123 | 100 | 0.058 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.043 | 0.021 | 0.043 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.084 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
