Two sample MR report
Type 2 diabetes || id:ebi-a-GCST90018706 against Pancreatic cancer || id:ebi-a-GCST90018673
Date: 01 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 105 | 0.527 | 0.208 | 0.013 |
| Weighted median | 105 | 0.064 | 0.136 | 0.639 |
| Inverse variance weighted | 105 | 0.140 | 0.090 | 0.118 |
| Simple mode | 105 | -0.131 | 0.305 | 0.669 |
| Weighted mode | 105 | 0.094 | 0.184 | 0.608 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 121 | 103 | 0.105 |
| Inverse variance weighted | 126 | 104 | 0.068 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.04 | 0.02 | 0.043 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.044 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
