Two sample MR report
Type 2 diabetes || id:ebi-a-GCST90018706 against hepatocellular carcinoma || id:bbj-a-158
Date: 02 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 101 | -0.176 | 0.111 | 0.117 |
| Weighted median | 101 | -0.128 | 0.074 | 0.083 |
| Inverse variance weighted | 101 | -0.091 | 0.047 | 0.054 |
| Simple mode | 101 | -0.049 | 0.157 | 0.758 |
| Weighted mode | 101 | -0.126 | 0.103 | 0.222 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 120 | 99 | 0.072 |
| Inverse variance weighted | 121 | 100 | 0.075 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.009 | 0.01 | 0.402 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.088 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
