Two sample MR report
Type 2 diabetes || id:ebi-a-GCST90018926 against Colorectal cancer || id:ebi-a-GCST90018808
Date: 02 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 171 | -0.116 | 0.043 | 0.007 |
| Weighted median | 171 | -0.083 | 0.030 | 0.005 |
| Inverse variance weighted | 171 | -0.069 | 0.020 | 0.001 |
| Simple mode | 171 | 0.024 | 0.066 | 0.718 |
| Weighted mode | 171 | -0.104 | 0.032 | 0.001 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 244 | 169 | 0 |
| Inverse variance weighted | 246 | 170 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.004 | 0.003 | 0.212 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.066 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
