Two sample MR report
Type 2 diabetes || id:ebi-a-GCST90018926 against Colorectal cancer || id:ieu-b-4965
Date: 02 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 161 | 0.001 | 0.001 | 0.329 |
| Weighted median | 161 | 0.001 | 0.001 | 0.331 |
| Inverse variance weighted | 161 | 0.001 | 0.000 | 0.144 |
| Simple mode | 161 | 0.002 | 0.002 | 0.146 |
| Weighted mode | 161 | 0.001 | 0.001 | 0.355 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 202 | 159 | 0.012 |
| Inverse variance weighted | 202 | 160 | 0.013 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0 | 0 | 0.754 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.087 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
