Two sample MR report
Type 2 diabetes || id:ebi-a-GCST90018926 against ER+ Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) || id:ieu-a-1127
Date: 01 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 157 | 0.008 | 0.038 | 0.841 |
| Weighted median | 157 | -0.013 | 0.021 | 0.530 |
| Inverse variance weighted | 157 | -0.018 | 0.018 | 0.325 |
| Simple mode | 157 | -0.062 | 0.055 | 0.258 |
| Weighted mode | 157 | 0.060 | 0.026 | 0.024 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 465 | 155 | 0 |
| Inverse variance weighted | 466 | 156 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.002 | 0.003 | 0.442 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.237 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
