Two sample MR report
Type 2 diabetes || id:ebi-a-GCST90018926 against Liver & bile duct cancer || id:ieu-b-4915
Date: 02 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 144 | 0 | 0 | 0.733 |
| Weighted median | 144 | 0 | 0 | 0.392 |
| Inverse variance weighted | 144 | 0 | 0 | 0.942 |
| Simple mode | 144 | 0 | 0 | 0.856 |
| Weighted mode | 144 | 0 | 0 | 0.364 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 180 | 142 | 0.018 |
| Inverse variance weighted | 180 | 143 | 0.020 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0 | 0 | 0.672 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.092 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
