Two sample MR report
Type 2 diabetes || id:ebi-a-GCST90018926 against Liver cell carcinoma || id:ieu-b-4953
Date: 02 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 131 | 0.000 | 0 | 0.529 |
| Weighted median | 131 | 0.000 | 0 | 0.626 |
| Inverse variance weighted | 131 | 0.000 | 0 | 0.834 |
| Simple mode | 131 | 0.001 | 0 | 0.066 |
| Weighted mode | 131 | 0.000 | 0 | 0.924 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 212 | 129 | 0 |
| Inverse variance weighted | 213 | 130 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0 | 0 | 0.415 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.147 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
