Two sample MR report
Type 2 diabetes || id:ebi-a-GCST90018926 against Malignant neoplasm of liver and intrahepatic bile ducts (all cancers excluded) || id:finn-b-C3_LIVER_INTRAHEPATIC_BILE_DUCTS_EXALLC
Date: 02 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 62 | -0.702 | 0.815 | 0.392 |
| Weighted median | 62 | -0.020 | 0.340 | 0.954 |
| Inverse variance weighted | 62 | 0.252 | 0.289 | 0.384 |
| Simple mode | 62 | 0.813 | 0.696 | 0.247 |
| Weighted mode | 62 | -0.008 | 0.698 | 0.991 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 91.6 | 60 | 0.005 |
| Inverse variance weighted | 93.9 | 61 | 0.004 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.059 | 0.047 | 0.216 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.917 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
