Two sample MR report
Type 2 diabetes || id:ebi-a-GCST90018926 against Pancreatic cancer || id:ebi-a-GCST90018893
Date: 01 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 171 | 0.047 | 0.109 | 0.667 |
| Weighted median | 171 | 0.088 | 0.081 | 0.279 |
| Inverse variance weighted | 171 | 0.078 | 0.053 | 0.138 |
| Simple mode | 171 | 0.224 | 0.176 | 0.203 |
| Weighted mode | 171 | 0.112 | 0.092 | 0.225 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 210 | 169 | 0.017 |
| Inverse variance weighted | 210 | 170 | 0.020 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.003 | 0.008 | 0.745 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.065 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
