Two sample MR report
Type 2 diabetes || id:ieu-a-23 against Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) || id:ieu-a-1126
Date: 01 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 25 | 0.174 | 0.072 | 0.024 |
| Weighted median | 25 | -0.003 | 0.027 | 0.921 |
| Inverse variance weighted | 25 | 0.006 | 0.031 | 0.852 |
| Simple mode | 25 | -0.033 | 0.061 | 0.589 |
| Weighted mode | 25 | 0.090 | 0.034 | 0.015 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 111 | 23 | 0 |
| Inverse variance weighted | 142 | 24 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.021 | 0.008 | 0.019 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.234 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
