Two sample MR report
Type 2 diabetes || id:ieu-a-23 against Colorectal cancer || id:ebi-a-GCST90018808
Date: 02 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 27 | -0.087 | 0.069 | 0.216 |
| Weighted median | 27 | -0.038 | 0.035 | 0.281 |
| Inverse variance weighted | 27 | -0.052 | 0.025 | 0.036 |
| Simple mode | 27 | 0.056 | 0.064 | 0.392 |
| Weighted mode | 27 | -0.047 | 0.048 | 0.344 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 19.8 | 25 | 0.756 |
| Inverse variance weighted | 20.1 | 26 | 0.785 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.004 | 0.008 | 0.589 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.148 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
